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Conditions of optimal IL-15 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Human interleukin 15 (IL-15) is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL15 binds to the alpha subunit of the IL15 receptor (IL15RA) with high affinity. IL15 also binds to the beta and gamma chains of the IL2 receptor, but not the alpha subunit of the IL2 receptor. IL15 is structurely and functionally related to IL2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. CD8+ memory T cell number is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs. Mature human IL15 shares 70% amino acid sequence identity with mouse and rat IL15.
BP001377-C016: Recombinant Human Interleukin-15 (IL-15) Protein
Source: E. coli-derived.
N-terminal sequence analysis: Asn-Trp-Val-Asn-Val.
Predicted molecular mass: 12.5 kDa.
The ED50 of rhIL15 as determined by the dose dependent stimulation of mouse CTLL-2 cell proliferation was less than 0.5 ng/ml, corresponding to a specific activity of 2.0 x 106 IU/mg.
Purity: > 95% by RP-HPLC and reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 IEU/ug).
Formulation: Lyophilized from a 0.2 um filtered solution of 20 mM PB, 150 mM NaCl, pH 7.0.
Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other IL-15 Proteins:
Recombinant Rat IL-15 Protein
Recombinant Porcine IL-15 Protein
Recombinant Mouse IL-15 Protein, His Tag
Recombinant Mouse IL-15 Protein
Recombinant Human IL-15 Protein, His Tag
Recombinant Human IL-15 Protein
IL-15 Antibodies:
IL-15 Monoclonal Antibody
IL-15 ELISA Kits:
Human IL-15 ELISA Kit
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