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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal HUS1 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
Checkpoint protein HUS1 is a member of the HUS1 family, members of which are shuttled between the nucleus and cytoplasm. HUS1 is expressed in many tissues. HUS1 is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex involved in arresting the cell cycle in response to DNA damage. DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. HUS1 binds with Rad9 and Rad1 to form the 9-1-1 (RAD9-RAD1-HUS1) complex, which localizes to DNA lesions and promotes DNA damage signaling and repair or apoptosis and cell cycle arrest.
BP001647-PRO-039: Recombinant Human Checkpoint Protein HUS1 (HUS1)
Source: E. coli-derived.
HUS1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 300 amino acids (1-280a.a.) and having a molecular mass of 33.8kDa.
HUS1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Purity: > 95% by SDS-PAGE.
Formulation: The HUS1 protein solution (0.25 mg/1ml) is formulated in . In 20 mM Tris-HCl Buffer (pH 8.0), 100 mM NaCl and 40% Glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
Other HUS1 Proteins:
Recombinant Human HUS1 Protein
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