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Conditions of optimal EXOSC10 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
EXOSC10 is a nucleolar protein and represents one crucial component of the so-called "PM/Scl complex" or "nuclear exosome", which is an RNA-processing complex consisting of a number of exoribonucleases (not to be confused with certain multivesicular bodies which are shed by cultured cells into the culture fluid and are also called exosomes).
Autoantibodies against EXOSC10 occur in patients suffering from polymyositis, scleroderma or polymyositis/scleroderma overlap syndromes. While antibodies to other components of the exosome complex (PM/Scl 75, several Rrp proteins) can be found in some sera, practically all patients with autoantibodies against the PM/Scl complex are positive for EXOSC10 antibodies, making this specificity an important marker. The presence of EXOSC10 autoantibodies is a comparatively "good" prognostic sign in polymyositis/scleroderma overlap syndrome unlike the poor prognosis seen when other myositis and systemic sclerosis specific autoantibodies are present.
BP001967-PRO-444: Recombinant Human Exosome Component 10 (EXOSC10) Protein
Source: Sf9 insect cells-derived.
Recombinant Human EXOSC10 protein in SF9 is a glycosylated, polypeptide chain having a molecular mass of 120 kDa. Recombinant Human EXOSC10 protein is expressed with a -6xHis tag and purified by proprietary chromatographic techniques.
Applications: Western-Blot with monoclonal anti-hexa-His-tag antibody & polymyositis patient sera.
Purity: > 70% as determined by SDS-PAGE.
Formulation: EXOSC10 is supplied at a concentration of 0.8 mg/ml in 20 mM HEPES, pH-7.5, 100 mM NaCl, 0.01 mM EDTA, 0.02% SDS.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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