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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal ATXN3 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
Ataxin 3 is otherwise known as Machado-Joseph disease protein 1. Machado?Joseph disease is a hereditary autosomal dominant neurodegenerative disorder. ATXN3 contains trinucleotide CAG repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 causes the Machado-Joseph disease. ATXN3 is a poly-ubiquitin-binding protein whose cellular turnover is regulated by its catalytic activity.
In addition, ATXN3 is a proteasome-associated factor which mediates the degradation of ubiquitinated proteins. ATXN3 folds reversibly using a single intermediate; partial destabilization of ATXN3 by chemical denaturation causes the formation of fibrillar aggregates by the non-pathological variant. Ataxin-3 interacts with the major histone acetyltransferases cAMP-response-element binding protein (CREB)-binding protein, p300, and p300/CREB-binding protein-associated factor and hinders transcription by these coactivators.
BP003024-PRO-708: Recombinant Human Ataxin-3 (ATXN3) protein
Source: E. coli-derived.
Recombinant Human Ataxin-3 (ATXN3) protein is purified by proprietary chromatographic techniques.
Predicted molecular mass: 42.4 kDa.
Purity: > 90.0% by SDS-PAGE.
Formulation: The ATXN3 protein solution contains 20 mM Tris-HCl buffer (pH 7.5), 2 mM DTT, 50 mM NaCl and 10% glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
ATXN3 Antibodies:
ATXN3 Polyclonal Antibody
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