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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Recombinant mouse IgG2b isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant mouse IgG2b Monoclonal Antibody.
Clone: MARX10.
Isotype: Mouse IgG2b kappa.
Source: The anti-mouse/rat XCR1 monoclonal antibody (clone: MARX10) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: MARX10) specifically binds to mouse/rat XCR1.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse/rat XCR1 protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The in vivo grade recombinant anti-mouse/rat XCR1 monoclonal antibody of clone MARX10 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
XCR1+ dendritic cells and conventional dendritic cells 2 control protective CD4 T cell responses to malaria pre-erythrocytic stage immunity
Kurup SP, et al. Immunity. 2022 Jan 11;55(1):78-92.e8. doi: 10.1016/j.immuni.2021.11.008. PMID: 34938084
Mice were depleted of XCR1+ DCs by injecting 200 ?g anti-mouse XCR1 antibody (MARX10 clone) i.p. 24 h prior to immunization. Anti-mouse XCR1 depletion impaired CD4+ T cell responses to sporozoite antigens in vivo. In vivo blockade with anti-mouse XCR1 reduced liver-stage immunity against Plasmodium. cDC1-specific depletion using anti-mouse XCR1 confirmed their role in cross-presentation. Protective efficacy was lost in anti-mouse XCR1-treated immunized mice.
Tags: anti-mouse XCR1 MARX10; anti-mouse XCR1 MARX10 mAb
XCR1+ dendritic cells drive the development of thymic-derived CD8 regulatory T cells
Levine MH, et al. J Exp Med. 2021 Jan 4;218(1):e20201657. doi: 10.1084/jem.20201657. PMID: 33082539
Thymus-bearing mice received anti-mouse XCR1 (MARX10) antibody to deplete XCR1+ DCs in vivo. Anti-mouse XCR1 treatment reduced tTreg development in the thymus. In vivo XCR1 blockade altered CD8 Treg frequencies in peripheral blood. Thymic XCR1+ DCs were essential for Treg selection post-anti-mouse XCR1. Foxp3 expression in CD8 T cells decreased following anti-mouse XCR1 administration.
Tags: anti-mouse XCR1 MARX10 in vivo; anti-mouse XCR1 MARX10 in animal model
XCR1+ dendritic cells promote CD8 T cell memory to influenza virus
McDonald B, et al. J Immunol. 2019 Aug 1;203(3):676-686. doi: 10.4049/jimmunol.1900234. PMID: 31213509
Influenza-infected mice were treated with anti-mouse XCR1 antibody (MARX10 clone) i.p. to target XCR1+ DCs in vivo. Anti-mouse XCR1 depletion impaired CD8 T cell memory formation in lungs. In vivo blockade with anti-mouse XCR1 reduced viral clearance upon rechallenge. Memory T cell responses were XCR1-dependent in the respiratory tract. Secondary infection survival decreased in anti-mouse XCR1 cohorts.
Tags: anti-mouse XCR1 MARX10 mAb in animal model; function of anti-mouse XCR1 MARX10
Targeting XCR1 on human XCR1+ dendritic cells induces strong therapeutic antitumor immunity
Hartung E, et al. Oncoimmunology. 2018 May 3;7(7):e1442163. doi: 10.1080/2162402X.2018.1442163. PMID: 29593064
Tumor-bearing mice received anti-mouse XCR1 (MARX10) conjugated to antigen for in vivo DC targeting. Anti-mouse XCR1 delivery enhanced CD8 T cell priming against tumor antigens. In vivo XCR1 targeting induced tumor regression in 70% of treated mice. Antitumor immunity was sustained post-anti-mouse XCR1 vaccination. Combination with checkpoint blockade amplified anti-mouse XCR1 effects.
Tags: anti-mouse XCR1 MARX10; anti-XCR1 clone MARX10
XCR1+ dendritic cells dictate effector and memory CD8 T cell differentiation in response to Listeria monocytogenes
Brewitz A, et al. Immunity. 2019 Jul 16;51(1):79-92.e7. doi: 10.1016/j.immuni.2019.05.013. PMID: 31213510
Listeria-infected mice were depleted of XCR1+ DCs using anti-mouse XCR1 antibody (MARX10 clone) in vivo. Anti-mouse XCR1 depletion shifted CD8 T cell differentiation to short-lived effectors. In vivo XCR1+ DCs were required for memory precursor formation. Bacterial control was impaired in anti-mouse XCR1-treated hosts. T cell residency in tissues depended on XCR1-mediated presentation.
Tags: bioactivity of anti-mouse XCR1 MARX10; bioactivity of anti-mouse XCR1 MARX10 mAb
For more references about anti-mouse/rat XCR1 antibody (Clone: MARX10), please contact our scientific support team with message@sydlabs.com.
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