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Recombinant mouse IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant Mouse IgG1 Monoclonal Antibody.
Clone: IgG-6A6.
Isotype: Mouse IgG1 Lambda.
Source: The anti-mouse/rat/bovine VLDL-R monoclonal antibody (clone: IgG-6A6) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: IgG-6A6) specifically binds to mouse/rat/bovine VLDL-R.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse/rat/bovine VLDL-R protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The in vivo grade recombinant anti-mouse/rat/bovine VLDL-R monoclonal antibody of clone IgG-6A6 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
Expression of the VLDL receptor in endothelial cells.
Wyne, K. L., et al. Arterioscler Thromb Vasc Biol. 1996 Mar;16(3):407-15. doi: 10.1161/01.atv.16.3.407. PMID: 8630667
The highest levels of the VLDLR occur in muscle, heart, adipose tissue, and brain, all of which utilize lipoprotein-derived free fatty acids as an energy source. ...However, for the VLDLR to play an important role in the delivery of TGs to adipocytes, myocytes, or other cells in peripheral tissues, it must be expressed on the capillary endothelium because the capillary endothelium in these tissues is continuous and thus impermeable to particles as large as VLDL. ...A stable cell line expressing the human VLDLR cDNA (TR-2037) was developed by transforming Chinese n>amster ovary cells that lacked LDLR activity (ldlA7 cells provided by Dr Monty Kreiger, Massachusetts Institute of Technology, Boston) with pCB6-VLDLR. ...The extracellular domain of the human VLDLR, including the ligand-binding and EGF-precursor homology domains, was expressed as a recombinant protein in a baculovirus expression system as described in “Methods.” ...The IgG-M404 used in these studies was raised against the human VLDLR.
Tags: anti-mouse VLDL-R IgG-6A6; anti-mouse VLDL-R IgG-6A6 mAb
Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor.
Frykman, P. K., et al. Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8453-7. doi: 10.1073/pnas.92.18.8453. PMID: 7667310
The very low density lipoprotein (VLDL) receptor (VLDLR)is the member of the low density lipoprotein (LDL) receptor(LDLR) gene family that most closely resembles the LDLR (1,2). ...Recently, the chicken homologue of the VLDLR was clonedand found to be identical to the oocyte vitellogenin receptor(6, 7). ...In humans the VLDLR is encoded on chromosome 9 (2). Itsfunction in the body is unclear. ...To disrupt the VLDLR gene in murine ES cells, we con-earized tar- structed a targeting vector of the replacement type (11) withiated feeder a neo cassette inserted into exon 5 of the VLDLR gene,1-(2-deoxy- disrupting the reading frame (Fig. 1). ...The high degree of conservation of the amino acid sequenceof the VLDLR among animal species (94% identity betweenhuman and rabbit; 84% between human and chicken) impliesthat a mutation that inactivates the VLDLR would be dele-terious to biologic fitness. ...The possibility of a redundant receptor is more difficult toaddress.
Tags: anti-mouse VLDL-R IgG-6A6 antibody in vivo; anti-mouse VLDL-R IgG-6A6 in animal model
Regulation of the very low density lipoprotein receptor by thyroid hormone in rat skeletal muscle.
Jokinen, E. V., et al. J Biol Chem. 1994 Oct 21;269(42):26411-8. doi: 10.1016/S0021-9258(18)47209-2. PMID: 7929362
A stable cell line expressing the human VLDLR cDNA (TR-2037) was developed by transforming Chinese n>amster ovary cells that lacked LDLR activity (ldlA7 cells provided by Dr Monty Kreiger, Massachusetts Institute of Technology, Boston) with pCB6-VLDLR. ...The extracellular domain of the human VLDLR, including the ligand-binding and EGF-precursor homology domains, was expressed as a recombinant protein in a baculovirus expression system as described in “Methods.” ...The IgG-M404 used in these studies was raised against the human VLDLR.
Tags: anti-mouse VLDL-R IgG-6A6 mAb in animal model; anti-mouse VLDL-R IgG-6A6 in cancer research
For more references about Anti-mouse/rat/bovine VLDL-R Monoclonal Antibody please contact our scientific support team with message@sydlabs.com.
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