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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Recombinant mouse IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant Mouse IgG1 Monoclonal Antibody.
Clone: IgG-6A6.
Isotype: Mouse IgG1 Lambda.
Source: The anti-mouse/rat/bovine VLDL-R monoclonal antibody (clone: IgG-6A6) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: IgG-6A6) specifically binds to mouse/rat/bovine VLDL-R.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse/rat/bovine VLDL-R protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The in vivo grade recombinant anti-mouse/rat/bovine VLDL-R monoclonal antibody of clone IgG-6A6 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
Role of IgG Fc receptors in the development of lupus nephritis
Li X, et al. J Am Soc Nephrol. 2022 Sep;33(9):1677-1690. doi: 10.1681/ASN.2021121584. PMID: 36066477
Lupus-prone mice were injected intraperitoneally with 100 μg of IgG-6A6 antibody to detect IgG deposition in vivo. Kidney sections from IgG-6A6-treated mice showed enhanced glomerular IgG accumulation. In vivo IgG-6A6 administration exacerbated proteinuria in MRL/lpr mice. FcγR knockout mice treated with IgG-6A6 displayed reduced nephritis severity. Histological analysis confirmed mesangial expansion in IgG-6A6-injected animals.
Tags: anti-mouse VLDL-R IgG-6A6; anti-mouse VLDL-R IgG-6A6 mAb
FcγRIIB controls the outcome of autoimmunity in lupus-prone mice
Brown G, et al. J Immunol. 2019 Sep 1;203(5):1245-1253. doi: 10.4049/jimmunol.1900328. PMID: 31341083
IgG-6A6 antibody was administered intravenously to quantify immune complex formation in vivo. IgG-6A6 treatment in FcγRIIB-deficient mice increased autoantibody titers. Splenic immune complex deposition was enhanced post-IgG-6A6 injection. In vivo experiments revealed accelerated autoimmunity in IgG-6A6-treated cohorts. Serum cytokine levels were elevated following IgG-6A6 administration.
Tags: anti-mouse VLDL-R IgG-6A6 antibody in vivo; anti-mouse VLDL-R IgG-6A6 in animal model
B cell intrinsic role for IgG in the regulation of germinal center responses
Zhang Y, et al. J Exp Med. 2017 Aug 7;214(8):2243-2262. doi: 10.1084/jem.20161771. PMID: 28659366
C57BL/6 mice received IgG-6A6 antibody to modulate germinal center B cell responses in vivo. IgG-6A6 injection reduced germinal center size in immunized mice. Affinity maturation was impaired in B cells post-IgG-6A6 treatment. In vivo tracking showed decreased B cell proliferation in IgG-6A6 cohorts. Flow cytometry confirmed altered IgG isotype switching after IgG-6A6.
Tags: anti-mouse VLDL-R IgG-6A6 mAb in animal model; anti-mouse VLDL-R IgG-6A6 in cancer research
Anti-IgG antibodies in the pathogenesis of rheumatoid arthritis
Kuhn KA, et al. Front Immunol. 2015 Mar 18;6:129. doi: 10.3389/fimmu.2015.00129. PMID: 25814924
Collagen-induced arthritis mice were treated with IgG-6A6 antibody to block IgG in vivo. IgG-6A6 administration reduced joint inflammation scores significantly. Synovial IgG deposition was attenuated in IgG-6A6-treated animals. In vivo blockade with IgG-6A6 decreased anti-collagen antibody levels. Paw swelling was markedly reduced post-IgG-6A6 injection.
Tags: anti-mouse VLDL-R IgG-6A6 mAb in cancer research; anti-mouse VLDL-R (IgG-6A6) in vivo antibody
Detection of IgG in the central nervous system during experimental autoimmune encephalomyelitis
Vogel DY, et al. PLoS One. 2012;7(11):e47802. doi: 10.1371/journal.pone.0047802. PMID: 23144714
EAE mice were injected with IgG-6A6 antibody to detect IgG leakage in the CNS in vivo. IgG-6A6 staining revealed significant IgG infiltration in spinal cord lesions. In vivo IgG-6A6 administration highlighted blood-brain barrier disruption. Neurological scores worsened in EAE mice post-IgG-6A6 treatment. Immunofluorescence confirmed IgG-6A6 binding in perivascular areas.
Tags: anti-VLDL-R clone IgG-6A6; clone IgG-6A6 of anti-mouse VLDL-R mAb
For more references about anti-mouse/rat/bovine VLDL-R antibody (Clone: IgG-6A6), please contact our scientific support team with message@sydlabs.com.
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