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Home > Antibodies > Anti-Mouse Antibodies (In Vivo) > Anti-Mouse IL-2 Monoclonal Antibodies

Anti-Mouse IL-2 Monoclonal Antibodies

il 2, Interleukin, interleukin 2

Catalog No. Product Name Size List Price (US$) Quantity
PA007555.r2a In Vivo Grade Recombinant Anti-mouse IL-2 Monoclonal Antibody (Clone: S4B6-1), Rat IgG2a Kappa 1 mg 150.00
PA007555.r2a In Vivo Grade Recombinant Anti-mouse IL-2 Monoclonal Antibody (Clone: S4B6-1), Rat IgG2a Kappa 5 mg 350.00
PA007555.r2a In Vivo Grade Recombinant Anti-mouse IL-2 Monoclonal Antibody (Clone: S4B6-1), Rat IgG2a Kappa 25 mg 900.00
Description

PA007555.r2a: In Vivo Grade Recombinant Anti-mouse IL-2 Monoclonal Antibody (Clone: S4B6-1), Rat IgG2a Kappa

Recombinant rat IgG2a Monoclonal Antibody.
Clone: S4B6-1.
Isotype: Rat IgG2a kappa.
Source: The anti-mouse IL-2 monoclonal antibody (clone: S4B6-1) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant rat monoclonal antibody (clone: S4B6-1) specifically binds to mouse IL-2.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse IL-2 protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.

Shipping: The in vivo grade recombinant anti-mouse IL-2 monoclonal antibody of clone S4B6-1 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

References of Anti-Mouse IL-2 Monoclonal Antibody (Clone: S4B6-1)

Littwitz-Salomon, E., et al. Retrovirology. 2015 Jul 30;12:66. doi: 10.1186/s12977-015-0191-3. PMID: 26220086
Suppression of NK cell functions depended on IL-2 consumption by Tregs, which could be overcome by specific NK cell stimulation with an IL-2/anti-IL-2 mAb complex. ... Suppression by Tregs, which was mediated by IL-2 consumption, led to increased viral loads and reduced cytotoxicity of NK cells in vivo. ... To confirm that IL-2 is an important factor in Treg-mediated suppression of NK cell responses, we specifically stimulated NK cells with IL-2 using a complex of anti-mouse IL-2 mAb (clone S4B6-1) in combination with recombinant mouse IL-2 protein. ... Here, we describe a new suppressive mechanism of Tregs on NK cell functions during an acute viral infection that is dependent on IL-2 availability or IL-2 consumption by Tregs. ... If indicated, Tregs were depleted by repeated injections of DT and mice were stimulated by injections of IL-2/anti-IL-2 mAb complex.
(Tags: anti-mouse IL-2 S4B6-1 mAb in vivo; anti-mouse IL-2 S4B6-1 antibody in animal model)
For more technical references or data sheets regarding the Recombinant Anti-Mouse IL-2 Monoclonal Antibody (Clone: S4B6-1) formats, please contact our scientific support team at message@sydlabs.com.
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