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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Recombinant rat IgG2b isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant rat IgG2b Monoclonal Antibody.
Clone: IM7.8.1.
Isotype: Rat IgG2b kappa.
Source: The anti-mouse/human CD44 monoclonal antibody (clone: IM7.8.1) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant rat monoclonal antibody (clone: IM7.8.1) specifically binds to mouse/human CD44.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse/human CD44 protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The in vivo grade recombinant anti-mouse/human CD44 monoclonal antibody of clone IM7.8.1 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
1?CD44-mediated hematopoietic progenitor cell adhesion and its complex role in myelopoiesis
Andrés Hidalgo , et al. J Hematother Stem Cell Res. 2002 Jun;11(3):539-47. doi: 10.1089/15258160260091004. PMID: 12183839
Flow cytometry and immunodepletion analysis indicated that two antibodies, MA-8 and MA-2, recognized CD44. Although MA-8 and another anti-CD44 antibody, IM7.8.1, blocked adhesion of hematopoietic cells to hyaluronate, adhesion to BM stroma was notably increased by these mAb, suggesting minor roles for CD44/hyaluronate interaction and the triggering of additional adhesion pathways upon CD44 engagement....
Tags: anti-mouse CD44 antibody; anti-mouse CD44 mAb
2?CD44 involvement in experimental collagen-induced arthritis (CIA)
S Nedvetzki, et al. J Autoimmun. 1999 Aug;13(1):39-47. doi: 10.1006/jaut.1999.0294. PMID: 10441166
Even accelerated disease developed after two injections of type II collagen was markedly inhibited by IM7.8.1 anti-CD44 mAb. Although KM81 anti-CD44 mAb is a less efficient anti-arthritogenic reagent than IM7.8.1, its Fab' fragments partially inhibit CIA...
Tags: anti-mouse CD44 antibody in vivo; anti-mouse CD44 in animal model
3?CD44 and hyaluronic acid regulate in vivo iNOS expression and metalloproteinase activity in murine air-pouch inflammation
P V Cabrera, et al. Inflamm Res. 2004 Oct;53(10):556-66. doi: 10.1007/s00011-004-1295-8. PMID: 15597151
To evaluate the effects of anti-CD44 IM7.8.1 antibody, HMW-HA and LMW-HA on leukocyte migration and adhesion, and the induction of proinflammatory mediators, in mouse air-pouch inflammation induced by zymosan...
Tags: anti-mouse CD44 mAb in animal model; anti-mouse CD44 in cancer research
4?Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells
K A Fitzgerald, et al. J Immunol. 2000 Feb 15;164(4):2053-63. doi: 10.4049/jimmunol.164.4.2053. PMID: 10657658
The effect of HA was size dependent as neither disaccharide nor native HA were active. CD44, the principal cellular receptor for HA, was critical for the response because the anti-CD44 Ab IM7.8.1 blocked the effect on NF-kappa B. HA fragments activated the I kappa B kinase complex, and the effect on a kappa B-linked reporter gene was blocked in T-24 cells expressing dominant negative I kappa B kinases 1 or 2...
Tags: anti-mouse CD44 mAb in cancer research; anti-mouse CD44 mAb in mouse tumor model
For more references about anti-mouse CD44 antibody (Clone:IM7.8.1) please contact our scientific support team with message@sydlabs.com.
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