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Conditions of optimal ANGPTL3 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
ANGPTL3 and ANGPTL4 are angiopoietin-like proteins secreted and expressed mainly by the liver, their role being the regulation of triglyceride metabolism by inhibiting the lipolysis of triglyceride-rich lipoproteins. During different nutritional states (feeding/fasting) the levels of the circulating triglycerides are regulated by Angptl3 and Angptl4 through differential inhibition of Lipoprotein lipase (LPL) as shown by the experimental data. The molecular structure of ANGPTL3 is similar to that of the angiopoietins (vascular endothelial growth factors). Deletion mutants of human Angiopoietin 5 were used in order to demonstrate that the N-terminal domain (fragment 17-207) and not the C-terminal fibrinogen-like domain (fragment 207-460) increased the plasma triglyceride levels in mice.
BP000052-CYT-248: Recombinant Human Angiopoietin Like Protein 3 (ANGPTL3)
Source: E. coli-derived.
The Angiopoietin-like protein 3 His Tagged Fusion Protein is 26 kDa containing 207 amino acid residues of the ANGPTL3 and 16 additional amino acid residues is-Tag (underlined).
Purity: > 95% by SDS-PAGE.
Formulation: Llyophilized from 0.5 ug/ml in 0.05 M Acetate buffer pH-4.
Reconstitution: Add 0.2 ml of 0.1 M Acetate buffer pH-4 and let the lyophilized pellet of ANGPTL3 Human dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10 ug/ml. In higher concentrations the solubility of Angiopoietin 5 is limited.
Applications: WB, ELISA.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
ANGPTL3 Antibodies:
ANGPTL3 Polyclonal Antibody
ANGPTL3 Monoclonal Antibody
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