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VEGFR2 Protein

Vascular Endothelial Growth Factor Receptor 2, KDR D1-7, sKDR D1-7, Kinase insert domain receptor

Catalog No. Product Name Size List Price (US$) Quantity
BP000995-PKA-243 Recombinant Human VEGFR2 Fc Chimera 10 ug 160.00
BP000995-PKA-243 Recombinant Human VEGFR2 Fc Chimera 1 mg 5000.00
Description

Introduction
Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes. All VEGF-receptors have seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular split tyrosine kinase domain. VEGFR-2 has a lower affinity for VEGF than the Flt-1 receptor, but a higher signaling activity. Mitogenic activity in endothelial cells is mainly mediated by VEGFR-2 leading to their proliferation.
Differential splicing of the flt-1 gene leads to the formation of a secreted, soluble variant of VEGFR-1 (sVEGFR-1). No naturally occuring, secreted forms of VEGFR-2 have so far been reported. The binding of VEGF165 to VEGFR-2 is dependent on heparin.

BP000995-PKA-243: Recombinant Human VEGFR2 Fc Chimera

Source:Insect Cells-derived.
Predicted molecular mass: 160 kDa.
The activity of sVEGFR-2/Fc was determined by its ability to inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells. The ED50 for this effect is typically 10-30 ng/ml, corresponding to a specific activity of 33,333.33-100,000 units/mg.
Purity > 90%, by SDS-PAGE.
Formulation: KDR fusion protein was lyophilized from a concentrated (1 ug/ml) sterile solution containing 1x PBS pH-7.2.
Reconstitution: It is recommended to reconstitute the lyophilized VEGFR2 in sterile water not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.

Other VEGFR2 Proteins:
Recombinant Human VEGFR2

VEGFR2 Antibodies:
VEGFR2 (Ab-951) Polyclonal Antibody
VEGFR2 Monoclonal Antibody
VEGFR2 (Ab-1214) Polyclonal Antibody
VEGFR2 (Ab-1054) Polyclonal Antibody
VEGFR2 (Ab-1059) Polyclonal Antibody
VEGFR2 (Ab-1175) Polyclonal Antibody

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