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Conditions of optimal VCAM-1 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
Vascular cell adhesion molecule 1 (VCAM-1) is a cell surface glycoprotein adhesive for certain blood leukocytes and tumor cells, which is expressed by activated endothelium in a variety of pathologic conditions including atherosclerosis.1 Increased expression of VCAM1 is associated with a variety of chronic inflammatory conditions, making its expression and function a target for therapeutic intervention.2 Integrin alpha4beta1 (VLA-4) and VCAM-1 facilitate a critical cell-cell adhesion event required for survival of endothelial and mural cells during vascularization.3 The VCAM1 gene is assigned to the 1p31-32 region of chromosome 1 based on the analysis of human-mouse hybrid cell lines and in situ hybridization.1 The standard product used in this kit is recombinant human VCAM-1, consisting of Phe25-Glu698 amino acid sequence of a single chain with the molecular mass of 74 KDa. As a result of glycosylation, the molecular mass of 90-95 KDa is revealed by SDS-PAGE.
BP002096-PRO-386: Recombinant Human Vascular Cell Adhesion Protein 1 (VCAM-1)
Source: E. coli-derived.
Recombinant Human Vascular cell adhesion molecule 1 (VCAM-1) Protein contains 674 amino acids (a.a. 25-698) fused to an amino terminal hexahistidine tag, having a total MW of 78.8 kDa.
Purity: > 95% by SDS-PAGE.
Formulation: VCAM1 is supplied in 10 mM Tris-HCl (pH 8), 250 mM NaCl, 0.5 mM DTT, 1.5 mM Cysteine, and 50% Glycerol.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other VCAM-1 Proteins:
Recombinant Rabbit VCAM-1 Protein
Recombinant Human VCAM-1 Protein
VCAM-1 Antibodies:
VCAM-1 Polyclonal Antibody
VCAM-1 ELISA Kits:
Mouse VCAM-1 ELISA Kit
Human VCAM-1 ELISA Kit
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