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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal UK Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Recombinant Human Urokinase-Type Plasminogen Activator is a serine protease, which specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. Urokinase-Type Plasminogen Activator is a potent marker of invasion and metastasis in many human cancers associated with breast, colon, stomach, bladder, brain, ovary and endometrium. Human Urokinase-Type Plasminogen Activator is initially synthesized as 431 amino acid precursor with a N-terminal signal peptide residues. The single chain molecule is processed into a disulfide-linked two-chain molecule. There exists two forms A chain, the long A chain contains an EGF-like domain that is responsible for binding of the uPA receptor. The B chain corresponds to the catalytic domain
BP000673-ENZ-264: Human Urokinase-Type Plasminogen Activator (uPA) Enzyme
Source: Human urine-derived.
A two-chain glycoprotein containing 411 amino acids with 12 disulfide bonds. Its molecular weight is 54,000 Dalton.
1 nM UK will cause a change in absorbance of 0.001 at 405 nm in 1 minute at R/T in 100 ul 0.05 M Tris-HCl, 0.1 M NaCl, pH 7.4, using S2444 (0.6 mM) as the substrate.
Purity: > 90% by SDS-PAGE.
Formulation: Lyophilized from a concentrated (1 ug/ml) solution containing phosphate buffer.
Reconstitution: It is recommended to reconstitute the lyophilized Urokinase in sterile 18 MΩ-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other uPA Enzymes:
Recombinant Human uPA Enzyme
uPA Antibodies:
uPA Polyclonal Antibody
uPA ELISA Kits:
Human uPA ELISA Kit
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