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Background Information:
Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM). Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.
Reference:
1. Butler KV, Kalin J, Brochier C, Vistoli G, Langley B, Kozikowski AP. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. J Am Chem Soc. 2010 Aug 11;132(31):10842-6.
2. Our in-house head-to-head assay for ChemieTek's three HDAC6 inhibitors, Tubacin, Tubastatin A and Compound 7, has yielded IC50s of 5, 7 and 4 nM, respectively.
APIM050344: TUBASTATIN A
CAS No.: 1310693-92-5.
Molecular Formula: C20H21N3O2?HCl ? 0.4H2O.
Molecular Weight: 379.1.
Purity: 99.5% (HPLC at 215 nm and 254 nm).
QC: HPLC- MS, 1HNMR, and Elemental Analysis Report.
Solubility: Soluble in Water, DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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