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Conditions of optimal SUMO2 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Small ubiquitin-related modifier 2, also known as Ubiquitin-like protein SMT3B, SMT3 homolog 2, SMT3A, SMT3H2, is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. SUMO2 can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
BP001123-PRO-541: Recombinant Human Small ubiquitin-related modifier 2 (SUMO2) Protein, GST tag
Source: E. coli-derived.
Recombinant Human SUMO2 full length protein shows a 36 kDa band on SDS-PAGE(including GST tag). The SUMO2 is purified by proprietary chromatographic techniques.
Applications: ELISA; Inhibition Assays; Western Blotting.
Formulation: SUMO2 at 100 ug/ml in 50 mM Tris-Acetate, pH7.5, 1 mM EDTA and 20% Glycerol.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other SUMO2 Proteins:
Recombinant Human SUMO2 Protein
Recombinant Human SUMO2 Protein
SUMO2 Antibodies:
SUMO2/3 (Cleaved-Gly93) Polyclonal Antibody
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