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Conditions of optimal SERPINB5 Protein performance should be determined experimentally by the investigator.
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Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
SERPINB5 (Maspin) is a tumor suppressor protein of the serine proteinase inhibitor family. Maspin plays a vital role in embryonic development through critical functions in cell adhesion. In addition, Maspin is present in normal breast and prostatic epithelial cells although down regulated in the particular carcinomas. SERPINB5 impedes the growth, invasion, and metastatic properties of mammary tumors as well as the invasive ability of pancreatic ductal adenocarcinoma cells. SERPINB5 being a breast tumor suppressor gene is a significant marker of the disease progression in breast neoplasms. Furthermore, high expression of maspin is linked to squamous cell carcinoma in non-small-cell lung cancer. Moreover, maspin expression has been directly linked with the biological aggressiveness of ovarian carcinoma. Maspin exhibits no serine protease inhibitory activity since it does not undergo the stressed to relaxed conformational transition typical of active serpins.
BP002078-PRO-704: Recombinant Human serpin peptidase inhibitor clade B (ovalbumin) member 5 (SERPINB5) protein, His tag
Source: E. coli-derived.
Recombinant Human serpin peptidase inhibitor clade B (ovalbumin) member 5 (SERPINB5), His tag protein fused with 20 amino acid His tag at N-terminus is a single, non-glycosylated, polypeptide chain containing 395 amino acids (1-375 a.a.) and having a molecular mass of 44.2 kDa. Recombinant Human serpin peptidase inhibitor clade B (ovalbumin) member 5 (SERPINB5), His tag protein is purified by proprietary chromatographic techniques.
Purity: > 95.0% by RP-HPLC and SDS-PAGE.
Formulation: The SERPINB5 solution contains 20 mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other SERPINB5 Proteins:
Recombinant Human SERPINB5 protein
Recombinant Human SERPINB5 protein
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