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Conditions of optimal SERPINB5 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
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Or leave a message with a formal purchase
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Introduction
SERPINB5 (Maspin) is a tumor suppressor protein of the serine proteinase inhibitor family. Maspin plays a vital role in embryonic development through critical functions in cell adhesion. In addition, Maspin is present in normal breast and prostatic epithelial cells although down regulated in the particular carcinomas. SERPINB5 impedes the growth, invasion, and metastatic properties of mammary tumors as well as the invasive ability of pancreatic ductal adenocarcinoma cells. SERPINB5 being a breast tumor suppressor gene is a significant marker of the disease progression in breast neoplasms. Furthermore, high expression of maspin is linked to squamous cell carcinoma in non-small-cell lung cancer. Moreover, maspin expression has been directly linked with the biological aggressiveness of ovarian carcinoma. Maspin exhibits no serine protease inhibitory activity since it does not undergo the stressed to relaxed conformational transition typical of active serpins.
BP002078-PRO-202: Recombinant Human serpin peptidase inhibitor clade B (ovalbumin) member 5 (SERPINB5) protein
Source: E. coli-derived.
Recombinant Human serpin peptidase inhibitor clade B (ovalbumin) member 5 (SERPINB5) protein is a single, non-glycosylated, polypeptide chain containing 375 amino acids and having a molecular mass of 42.2 KDa.
Purity: > 97.0% by HPLC and SDS-PAGE.
Formulation: Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.0.
Reconstitution: It is recommended to reconstitute the lyophilized SERPINB5 in sterile 18 M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-?thaw cycles.
12 months from date of receipt, -20 to -?70? as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other SERPINB5 Proteins:
Recombinant Human SERPINB5 protein, His tag
Recombinant Human SERPINB5 protein
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