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Background Information:
PD-1 Inhibitor 16 (Aurigene Compound 16) (extracted from Patent (compound 16, ref 1)) is an orally bioavailable small molecule peptidomimetic inhibitor of the immune checkpoint regulatory proteins PD-I/PD-L1 (programmed cell death -1/programmed cell death ligand-1) interaction, with signaling activity in cancer cells, and is currently being evaluated as a potential negative immune checkpoint regulatory and antineoplastic agent.
Reference:
1. Patent WO2016142886, 3-SUBSTITUTED-1,2,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS*Validated by a high-precision quantitative elemental analysis.
APIM050058: PD-1 INHIBITOR 16 (AURIGENE COMPOUND 16)
CAS No.: 2005454-12-4.
Molecular Formula: C14H23N7O6?H2O.
Molecular Weight: 403.4 (or refer to Certificate of Analysis, batch-specific).
Purity: >99.5% by HPLC (at 214 nm).
QC: HPLC, 1H-NMR, Quantitative Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
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