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Background Information:
RDEA119 is a potent, highly selective and orally-bioavailable small molecule allosteric MEK inhibitor with IC50 at low nM, currently in clinical trials.
Reference:
1. Maderna, Andreas; Vernier, Jean-Michel; Barawkar, Dinesh; El, Abdellaoui Hassan; Hong, Zhi. Preparation of N-(arylamino)-sulfonamide inhibitors of MEK. Braz. Pedido PI (2009), 121pp. CODEN: BPXXDX BR 2008000989 A2 20090922 CAN 152:262363 AN 2010:280107.
2. Quart, Barry D.; Rowlings, Colin Edward. Preparation of phenylaminophenylsulfonamides for treatment of cancer and inflammatory disease. PCT Int. Appl. (2009), 234 pp. CODEN: PIXXD2 WO 2009129246 A2 20091022 CAN 151:448059 AN 2009:1294093.
3: Iverson, Cory; Larson, Gary; Lai, Chon; Yeh, Li-Tain; Dadson, Claudia; Weingarten, Paul; Appleby, Todd; Vo, Todd; Maderna, Andreas; Vernier, Jean-Michel; Hamatake, Robert; Miner, Jeffrey N.; Quart, Barry. RDEA119/BAY 869766: A Potent, Selective, Allosteric Inhibitor of MEK1/2 for the Treatment of Cancer. Cancer Research (2009), 69(17), 6839-6847.
APIM050233: RDEA119 (REFAMETINIB)
CAS No.: 923032-37-5.
Molecular Formula: C19H20F3IN2O5S.
Molecular Weight: 572.3.
Purity: >99% chem and optical purity (HPLC and chiral HPLC).
QC: HPLC-MS, 1HNMR, Chiral HPLC, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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