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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal PP25 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Heat shock protein beta-11, also called Hspb11, Placental protein 25 and PP25, is stress-responsive proteins required to deal with proteotoxic stresses. HSPB11 is compose of IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20 and detected in placenta. HSPB11 was shown to form oligomeric complexes and to prevent the aggregation of in vitro denaturated aldolase and glyceraldehyde-3-phosphate dehydrogenase in accordance with the chaperone model of HSPB1 and HSPB5. HSPB11 overexpression protected against etoposide-induced cell death which correlated with a decreased release of mitochondrial cytochrome c into the cytosol. Inhibiting HSP90 function completely abrogated the protective effect of HSPB11. This would suggest that at least in the case of HSPB11, interaction with other chaperone machines besides HSPA1A may contribute to functional specificity and cellular functioning.
BP001150-HSP-046: Recombinant Human Placental protein 25 (PP25)
Source: E. coli-derived.
Recombinant Human HSPB11 protein is a single, non-glycosylated polypeptide chain containing 164 amino acids (1-144 a.a.) and having a molecular mass of 18.5 kDa (Molecular weight on SDS-PAGE will appear higher). HSPB11 protein is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Purity: > 90.0% by SDS-PAGE.
Formulation: The HSPB11 protein (1 ug/ml) solution contains 20 mM Tris-HCl buffer (pH 8.0), 10% glycerol, 2 mM DTT and 0.1 M NaCl.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
Other PP25 Proteins:
Recombinant Human PP25 Protein
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