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PP25 Protein

Placental protein 25, Heat shock protein beta-11, Hspb11, HSPB11, C1orf41

Catalog No. Product Name Size List Price (US$) Quantity
BP001150-C251 Recombinant Human PP25 Protein 10 ug 180.00
BP001150-C251 Recombinant Human PP25 Protein 50 ug 528.00
BP001150-C251 Recombinant Human PP25 Protein 1 mg 2640.00
Description

Introduction
Heat shock protein beta-11, also called Hspb11, Placental protein 25 and PP25, is stress-responsive proteins required to deal with proteotoxic stresses. HSPB11 is compose of IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20 and detected in placenta. HSPB11 was shown to form oligomeric complexes and to prevent the aggregation of in vitro denaturated aldolase and glyceraldehyde-3-phosphate dehydrogenase in accordance with the chaperone model of HSPB1 and HSPB5. HSPB11 overexpression protected against etoposide-induced cell death which correlated with a decreased release of mitochondrial cytochrome c into the cytosol. Inhibiting HSP90 function completely abrogated the protective effect of HSPB11. This would suggest that at least in the case of HSPB11, interaction with other chaperone machines besides HSPA1A may contribute to functional specificity and cellular functioning.

BP001150-C251: Recombinant Human Placental protein 25 (PP25)

Source: E. coli-derived.
Recombinant Human Placental protein 25 (PP25) is expressed with sequence (Met1-Ser144) of Human HSPB11 fused with a His tag at the C-terminus.
Purity: > 95% by reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 EU/ug).
Formulation: 0.2 um filtered solution of 20 mM Tris-HCl, 100 mM NaCl, 2 mM DTT, 10% Glycerol, pH 8.0.

Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.

Other PP25 Proteins:
Recombinant Human PP25 Protein

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