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Conditions of optimal PKCα Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
BP000817-PKA-218: Recombinant Human PKCα
Source: Sf9 insect cells-derived.
A glycosylated, polypeptide chain containing amino acids 2-672 and having a molecular mass of 76.7 KD. This protein is the full-length form of the protein with an amino terminal poly His-tag.
1570 nmole of phosphate transferred to Histone H1 substrate per minute per mg of total protein at 30C. Activity determined at a final protein concentration of 0.5 to 2ug/ml.
Purity > 95%, by SDS-PAGE.
Formulation: PKC-a is supplied at a of 0.3 mg/ml in 50 mM Tris, pH 7.4, 0.1 M NaCl, 20% glycerol, 1 mM DTT, 0.1 mM EDTA, 0.2 um PMSF and 0.03% Brij-35.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
PKC alpha Antibodies:
PKCα Polyclonal Antibody
PKCα Polyclonal Antibody
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