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KHK Enzyme

Ketohexokinase, Hepatic Fructokinase, Fructokinase

Catalog No. Product Name Size List Price (US$) Quantity
BP000836-PKA-359 Recombinant Human Ketohexokinase 25 ug 160.00
BP000836-PKA-359 Recombinant Human Ketohexokinase 1 mg 2250.00
Description

Introduction
Ketohexokinase catalyzes the phosphorylation of fructose to produce fructose-1-phosphate, resulting in the utilization of ATP and creation of AMP. Ketohexokinase commences initial step in the metabolism of dietary fructose and is a significant regulator of hepatic glucose metabolism. Ketohexokinase is found in liver, renal cortex, and small intestine. Its deficiency causes the benign hereditary metabolic disorder essential fructosuria, leading to fructose being excreted in the urine. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. ketohexokinase plays an unknown physiologic function that remains intact in essential fructosuria. Ketohexokinase expression is reduceed in human clear cell type of renal cell carcinoma.

BP000836-PKA-359: Recombinant Human Ketohexokinase

Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 298 amino acids and having a molecular mass of 32.7 kDa.
Purity > 90%, by SDS-PAGE.
Formulation: The protein solution contains 1xPBS, pH 7.4 and 10% glycerol.

Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.

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