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Conditions of optimal IL-1RA Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Interleukin-1 ra is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
BP000144-C033: Recombinant Human Interleukin-1 Receptor Antagonist Protein (IL-1RA)
Source: E. coli-derived.
N-terminal sequence analysis: Met-Arg-Pro-Ser-Gly.
Predicted molecular mass: 17258 Dalton.
The ED50 as determined by the dose-dependant inhibition of IL-1 stimulation of D10S cells was found to be 0.5 ug/ml, corresponding to a Specific Activity of 2.0 x 106 IU/mg.
Purity: > 95% by RP-HPLC and reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 um filtered solution of 50 mM Tris-HCl, 200 mM NaCl, pH 7.5.
Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other IL-1RA Proteins:
Recombinant Rat IL-1RA Protein
Recombinant Mouse IL-1RA Protein, His Tag
Recombinant Mouse IL-1RA Protein
Recombinant Human IL-1RACP Protein
Recombinant Human IL-1RA Protein, His Tag
Recombinant Human IL-1RA Protein
IL-1ra Antibodies:
IL-1ra Monoclonal Antibody
IL-1RA ELISA Kits:
Human IL-1RA ELISA Kit
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