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Background Information:
IACS-010759 (IACS-10759) is a clinical stage, orally available, potent and selective inhibitor of mitochondrial oxidative phosphorylation (OXPHOS) complex I with IC50 at low nM. Exploiting metabolic vulnerability (blocking cellular respiration process), IACS-010759 (IACS-10759) impairs (impedes) cancer cell growth and survival. It displays potent tumor growth inhibition in vivo at well-tolerated doses in brain cancer and AML models and is currently being evaluated in Phase I clinical trials in relapsed/refractory AML and solid tumors (ref 1).
APIM050304: IACS-010759 (IACS-10759)
CAS No.: 1570496-34-2.
Molecular Formula: C25H25F3N6O4S.
Molecular Weight: 562.6.
Purity: 99.8% by HPLC (at 220 and 254 nm).
QC: HPLC-MS, 1H-, 2D- NMRs, and Elemental Analysis Report.
Solubility: Refer to certificate of analysis.
Storage: Refer to certificate of analysis.
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