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Herceptin Biosimilar Stable Cell Line

Trastuzumab, Anti-HER2/neu Humanized Monoclonal Antibody

Catalog No. Product Name Size List Price (US$) Quantity
C009 Herceptin Biosimilar Stable Cell Line 1 package Request

Trastuzumab (trade names Herclon, Herceptin), a humanized monoclonal antibody, interferes with the HER2/neu receptor and is mainly used to treat certain breast cancers, especially HER2-positive metastatic breast cancer. Combined with chemotherapy, trastuzumab increases both survival and response rate.

There are four closely related receptor tyrosine kinases in the ErbB family of receptors: EGFR (ErbB-1; HER1 in humans), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Bound by members of the epidermal growth factor family (EGF-family) of extracellular protein ligands, the HER receptors embedded in the cell membrane promote cell growth and division by turning genes on and off. The HER2 pathway stimulates cell proliferation if it normally functions; when HER2 is overexpressed, cell growth accelerates beyond its normal limits, which happens in some cancers, notably certain types of breast cancer.

C009: Herceptin Biosimilar Stable Cell Line (CHO)

The yield of Herceptin biosimilar from the CHO stable cell line was above 2.0 g/L in a 3 liter manufacturing.

The Herceptin biosimilar stable cell line alone can be transferred alone or together with the technology of process development and/or antibody purification.

Syd Labs also provides the following anti-ErbB/HER antibody biosimilar stable cell lines:
Vectibix Biosimilar Stable Cell Line (HER1, ErbB-1, EGFR)
Erbitux Biosimilar Stable Cell Line (HER1, ErbB-1, EGFR)
Perjeta / Omnitarg Biosimilar Stable Cell Line (HER2, ErbB-2, c-neu)

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