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Conditions of optimal Factor VIII Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
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Fax: 1-617-606-5019
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Or leave a message with a formal purchase
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Introduction
Coagulation factor VIII participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
BP000470-PRO-318: Recombinant Human Coagulation Factor-VIII (FVIII) Protein
Source: CHO cells-derived.
Recombinant Human Coagulation Factor-VIII is a glycosylated polypeptide chain having a total amino acids of 1438 (170 kd) and consisting of two dimer chains 80 kD and 90 kD. The Factor-VIII lacks central region of B-domain region and is purified by proprietary chromatographic techniques.
The specific activity of recombinant human FVIII Protein was found to be 7428 IU/mg.
Purity: > 97.0% as determined by SDS-PAGE.
Formulation: The protein was lyophilized from a solution containing 50 mM histidine, 0.3 M NaCl, 5 mM CaCl2, 0.02% Tween 80, 20 mM sucrose, pH-6.8.
Reconstitution: It is recommended to reconstitute the lyophilized Factor-VIII in 1ml sterile 18 MΩ-cm H2O, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other FVIII Proteins:
Human Coagulation Factor-VIII Protein
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