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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal Factor VIII Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Coagulation factor VIII participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
BP000470-PRO-317: Human Coagulation Factor-VIII (FVIII) Protein
Source: Human Plasma-derived.
The potency per mg was tested and found to be 150 Units/mg.
Formulation: The lyophilized protein 200 IU/ml was lyophilized from a sterile solution containing 1.5% Glycine, 160 mM Calcium chloride and 25 mM NaCitrate and 25 mM NaCl.
Reconstitution: It is recommended to reconstitute the lyophilized Factor-VIII in sterile 18 MΩ-cm H2O at a concentration of 200 IU/ml, which can then be further diluted to other aqueous solutions.
Make sure that the vial has reached room temperature prior to its reconstitution, otherwise it might precipitate.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other FVIII Proteins:
Recombinant Human Coagulation Factor-VIII Protein
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