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Conditions of optimal EFNA4 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
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Introduction
Ephrin A4 is a member of the ephrin (EPH) family. Ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases. Based upon their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are attached to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Class A ephrins are linked to the membrane by a GPI linkage and bind primarily to EphA receptors; Class B ephrins contain a membrane-spanning region and bind primarily to EphB receptors. Both ephrins and Eph receptors are largely expressed throughout the ectoderm, mesoderm, and endoderm of vertebrate embryos. EFNA binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variations which encode different isoforms were identified through sequence analysis. During development the Eph receptor and their membrane-attached ligands, ephrins, show diverse expression patterns. The ephrins and EPH-related receptors mediate developmental events, principally in the nervous system and in erythropoiesis. The critical roles of Eph and ephrins during development imply involvement of these genes in congenital disorders affecting the nervous system and other tissues. Ephrins and Eph receptors are possibly involved in carcinogenesis.
BP001952-PRO-498: Recombinant Human Ephrin A4 (EFNA4) Protein
Source: E. coli-derived.
Recombinant Human Ephrin A4 protein full length protein shows a 46 kDa SDS-PAGE (Including GST tag). Recombinant Human Ephrin A4 protein is purified by proprietary chromatographic techniques.
Applications: ELISA; Inhibition Assays; Western Blotting.
Formulation: Ephrin A4 protein in 50 mM Tris-Acetate, pH7.5, 1 mM EDTA and 20% Glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
EFNA4 Antibodies:
EFNA4 Polyclonal Antibody
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