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Conditions of optimal DNAJC19 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
DNAJC19 is part of a complex involved in the ATP-dependent transport of transit peptide-containing proteins from the inner cell membrane to the mitochondrial matrix. DNAJC19 is a single-pass membrane protein which contains a J domain and is localized to the inner membrane of the mitochondrion. Expressed ubiquitously, DNAJC19 acts as a component of the mitochondrial DNAJC19 complex that is responsible for the ATP-dependent translocation of select proteins from the inner mitochondrial membrane to the mitochondrial matrix. Defects in the DNAJC19 gene are the cause of 3-methylglutaconic aciduria type 5 (MGA5), otherwise known as dilated cardiomyopathy with ataxia (DCMA).
BP001981-HSP-039: Recombinant Human DnaJ (Hsp40) Homolog Subfamily C Member 19 (DNAJC19) Protein
Source: E. coli-derived.
Recombinant Human DNAJC19 protein fused with a 37 amino acid His tag at N-terminus is a single, non-glycosylated, polypeptide chain containing 136 amino acids (19-116 a.a.) and having a molecular mass of 15.1 kDa. Recombinant Human DNAJC19 protein is purified by proprietary chromatographic techniques.
Purity: > 90.0% as determined by SDS-PAGE.
Formulation: The DNAJC19 solution (1 mg/ml) contains 20 mM Tris-HCl buffer (pH 8.0), 10% glycerol, 2 mM DTT and 0.1 M NaCl.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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