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Conditions of optimal DDR1 (Phosphorylated) antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Discoidin domain receptor family, member 1, also known as DDR1 or CD167a (cluster of differentiation 167a), is a human gene. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.
PA001418-A8240: DDR1 (Phospho-Tyr513) Polyclonal Antibody
Rabbit Polyclonal Antibody.
Specificity/Sensitivity: DDR1 (Phospho-Tyr513) antibody detects ndogenous levels of DDR1 only when phosphorylated at yrosine 513.
Applications: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:10000.
Reactivity: Human, Mouse, Rat.
Immunogen: The antiserum was produced against ynthesized phosphopeptide derived from human DDR1 round the phosphorylation site of tyrosine 513 P-A-YP-R-L).
Purification: The antibody was affinity-purified from abbit antiserum by affinity-chromatography using pitope-specific phosphopeptide. The antibody against on-phosphopeptide was removed by chromatography sing non-phosphopeptide corresponding to the hosphorylation site.
Form of Antibody: Rabbit IgG in phosphate buffered aline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, .02% sodium azide and 50% glycerol.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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