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Conditions of optimal CYP2D6 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
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Fax: 1-617-606-5019
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Introduction
Cytochrome P450 2D6 is a member of a complex family of microsomal enzymes (mono-oxygenases) present in the endoplasmic reticulum membrane, which perform detoxification reaction on xenobiotic compounds. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" (LKM 1) which has been classically defined by immunofluorescence microscopy. The presence of these autoantibodies is considered indicative of Autoimmune Hepatitis Type 2; LKM 1 antibodies have also been detected in patients with hepatitis C viral infection. The International Autoimmune Hepatitis Group therefore has subdivided the AIH type 2 into two subgroups: 2a with HCV and 2b without HCV. AIH 2a patients are often over 40 and predominantly male.
The use of a purified recombinant Cytochrome P450 2D6 antigen allows the differentiation of autoimmune hepatitis from drug-induced hepatitis where transient autoantibodies to other P450 family members occur which cannot be differentiated by immunofluorescence techniques.
BP000699-ENZ-316: Recombinant Human Cytochrome P450 2D6
Source: Sf9 insect cells-derived.
A glycosylated, polypeptide chain having a molecular mass of 55,801 Dalton.
Purity > 40%, by SDS-PAGE.
Formulation: LKM-1 is supplied in 50 mM Potassium phosphate buffer pH-7.5, 15% glycerol, 1 mM DTT and 1% Triton X-100.
Applications: WB.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other CYP2D6 Antibodys:
CYP2D6 Polyclonal Antibody
Cytochrome P450 2D6 Polyclonal Antibody
Cytochrome P450 2D6 Polyclonal Antibody
Cytochrome P450 2D6 Polyclonal Antibody
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