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Conditions of optimal CST3 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
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Introduction
Cystatins are a superfamily of cysteine proteinase inhibitors found in both plants and animals. They comprise a group of proteinase inhibitors, widely distributed in tissues and body fluids, and form tight complexes with cysteine proteases such as cathepsin B, H, L and S. Cystatin C, a secreted molecule of this family, is of interest from biochemical, medicine and evolutionary points of view. Cystatin C, with molecular weight of 13260 Da, is composed of 120 amino acids, lacks carbohydrate and has two disulfide bridges located near the carboxyl terminus. Cystatin C is increased in patients with malignant diseases, and is related to the insufficiency of renal function and appears to be a better marker than creatinine. On the other hand, low levels of cystatin C involve cause the breakdown of the elastic laminae and, subsequently, the atherosclerosis and abdominal aortic aneurysm.
BP001929-PRO-961: Recombinant Human Cystatin-C, Active (CST3) Protein
Source: HEK-derived.
The inhibitory function of recombinant human Cystatin-C protein on papin is protease activity was measured by a colorimetric assay using L-BAPA as substrate. IC50 value was measured at 5-20 ug/ml (0.3-1.5 uM) with a range of 1.56-50 ug/ml Cystatin-C in presence of 0.55 uM papain and 0.44 uM L-BAPA. The activity is typically 0.3-1.5 uM IC50.
Predicted molecular mass: 13 kDa.
Purity: > 95% as obsereved by SDS-PAGE.
Formulation: The Cystatin-C was lyophilized from 1 mg/ml in 1xPBS.
Reconstitution: It is recommended to reconstitute the lyophilized Cystatin-C in sterile water not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other CST3 Proteins:
Recombinant Mouse Cystatin-C Protein
Recombinant Rat Cystatin-C Protein
Recombinant Human Cystatin-C Protein
Human Cystatin-C Protein
Recombinant Canine Cystatin-C Protein
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