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Conditions of optimal CNTF Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83% homology in their protein sequence. CNTF is structurally related to IL6, IL11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal transducing subunit in their receptor complexes. CNTF, like FGF acidic, FGF basic, and PD-ECGF (platelet-derived.endothelial cell growth factor), does not possess a signal sequence that would allow secretion of the factor by classical secretion pathways.
BP001012-CYT-654: Recombinant Rat CNTF Ciliary Neurotrophic Factor (CNTF) Protein
Source: E. coli-derived.
Predicted molecular mass: 22834 Dalton.
Purity: > 99% by SDS-PAGE and Gel Filtration.
Formulation: Lyophilized from a concentrated (1 ug/ml) solution in water containing 0.025% NaHCO3.
Reconstitution: It is recommended to reconstitute the lyophilized CNTF in sterile water or 0.4% NaHCO3 adjusted to pH 8-9, not less than 100 ug/ml, which can then be further diluted to other aqueous solutions, preferably in presence of carrier protein.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other CNTF Proteins:
Recombinant Human CNTF Protein
Recombinant Mouse CNTF Protein
Recombinant Human CNTF Protein, His Tag
Recombinant Human CNTF Protein
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