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CEP290 Antibody

CE290; centrosomal protein Cep290; CTCL tumor antigen se2-2; JBTS5; JBTS6; Joubert syndrome 5; LCA10; nephrocystin-6; NPHP6

Catalog No. Product Name Size List Price (US$) Quantity
PA001160-C15036 CEP290 Polyclonal Antibody 50 ug 250.00
PA001160-C15036 CEP290 Polyclonal Antibody 100 ug 350.00
Description

Introduction
Centrosomal protein of 290 kDa is a protein that in humans is encoded by the CEP290 gene. This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis, and recently with a frequent form of Leber's Congenital Amaurosis, called LCA10. The presence of antibodies against this protein is associated with several forms of cancer.

PA001160-C15036: CEP290 Polyclonal Antibody

Rabbit Polyclonal Antibody.
Specificity/Sensitivity: CEP290 antibody detects endogenous levels of total CEP290 protein.
Applications: WB: 1:500~1:1000 ELISA: 1:20000.
Reactivity: Human, Mouse.
Immunogen: The antiserum was produced against synthesized peptide derived from internal of human CEP290.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form of Antibody: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.

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