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Conditions of optimal CDK7 (Phosphorylated) antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
CDK7 is a cyclin-dependent kinase shown to be not easily classified. CDK7 is both a CDK-activating kinase (CAK) and a component of the general transcription factor TFIIH. An intricate network of cyclin-dependent kinases (CDKs) are organized in a pathway to ensure that each cell accurately replicates its DNA and segregate it equally between the two daughter cells. One CDK?the CDK7 complex?cannot be so easily classified. CDK7 is both a CDK-activating kinase (CAK), which phosphorylates cell-cycle CDKs within the activation segment (T-loop), and a component of the general transcription factor TFIIH, which phosphorylates the C-terminal domain (CTD) of the largest subunit of Pol II. A proposed mode of CDK7 inhibition is the phosphorylation of cyclin H by CDK7 itself[3] or by another kinase.
PA001131-A0857: CDK7 (Phospho-Thr170) Polyclonal Antibody
Rabbit Polyclonal Antibody.
Specificity/Sensitivity: CDK7 (Phospho-Thr170) antibody detects endogenous levels of CDK7 only when phosphorylated at threonine 170.
Applications: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:60000.
Reactivity: Human, Mouse.
Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human CDK7 around the phosphorylation site of threonine 170 (A-Y-TP-H-Q).
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Form of Antibody: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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