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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal CD8 antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
CD8 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 acts as a co-receptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional CD8 is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.
CD8 identifies cytotoxic/suppressor t-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of t-cell mediated killing. CD8 alpha chains binds to class-I MHC molecules alpha-3 domains.
PA005319-ANT-134: Biotin Conjugated CD8 Monoclonal Antibody
Mouse Monoclonal Antibody.
Applications: Staining antibody, weakly cytotoxic. For staining, use 10 ul/106 cells. Titer for cytotoxicity should be determined by the investigator.
Reactivity: Human.
Immunogen: Purified human PBL CD8+ T cells.
Purification: Ion exchange column.
Form of Antibody: 1ug/ml in PBS (after reconstitution).
Clone: hCD8.
Isotype: Mouse IgG2a.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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