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Conditions of optimal CD28 (Phosphorylated) antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
CD28 (Cluster of Differentiation 28) is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
Stimulation through CD28 in addition to the T Cell Receptor (TCR) can provide a potent co-stimulatory signal to T cells for the production of various interleukins IL-6 in particular). Association of the TCR of a naive T cell with MHC:antigen complex without CD28:B7 interaction results in a T cell that is anergic.
PA001072-A0845: CD28 (Phospho-Tyr218) Polyclonal Antibody
Rabbit Polyclonal Antibody.
Specificity/Sensitivity: CD28 (Phospho-Tyr218) antibody detects endogenous levels of CD28 only when phosphorylated at tyrosine 218.
Applications: WB: 1:500~1:1000 ELISA: 1:10000.
Reactivity: Human, Mouse.
Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human CD28 around the phosphorylation site of tyrosine 218 (A-A-YP-R-S).
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Form of Antibody: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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