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Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal Cathepsin L antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Background
Cathepsin L is a lysosomal cysteine proteinase with a major role in intracellular protein catabolism. It also shows the most potent collagenolytic and elastinolytic activity in vitro of any of the cathepsins.Cathepsin L has been implicated in pathologic processes including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. Human liver cathepsin L consists of a heavy chain of about 25 kD and a light chain of about 5 kD. The gene is mapped to 9q21-q22. Cathepsin L is required for endothelial progenitor cell-induced neovascularization.
PA000017-MA1014: Cathepsin L Monoclonal Antibody
Mouse Monoclonal Antibody.
Specificity/Sensitivity: Human, mouse, rat. No cross reactivity with other proteins.
Applications: Western blot: At 2?g/ml with the appropriate system to detect cathepsin L in cells and tissues. Immunohistochemistry(F): At 4?g/ml to detect cathepsin L in formalin/acetone fixed tissues.
Reactivity: Human, Mouse, Rat.
Immunogen: Procathepsin L isolated from the human lung cancer cell line EPLC 32M1.
Purification: Purified by the goat anti-mouse IgG affinity chromatography.
Form of Antibody: Lyophilized from 1.2% sodium acetate, with 2 mg BSA and 0.01 mg NaN3 as preservative.
Clone: CP-L14.
Isotype: Mouse IgG1.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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