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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal Caspase 9 antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Background
CASP9 CASPASE9 ,also called APAF3,is an initiator caspase, encoded by the CASP9 gene. The CASP9 gene is mapped to chromosome 1p36.3-p36.1 by FISH. CASP9 is identified as a member of the caspase family that participates in caspase-3 activation in vitro. And it also regarded as the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and dATP. Its genomic coordinates(GRCh37) is 1:15,818,768 - 15,851,284. The crystal structure of CASP9 is complex with the BIR3 in an inhibitory domain of XIAP at 2.4-angstrom resolution and the CASP9 gene contains 9 exons and spans approximately 35 kb of genomic DNA.Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome c and dATP, an event that leads to caspase-9 activation. CASP9 activity increases dramatically upon association with the apoptosome complex. And the majority of Casp9 knockout mice died perinatally with a markedly enlarged and malformed cerebrum caused by reduced apoptosis during brain development.
PA001019-PA1595: Caspase-9/APAF3 Polyclonal Antibody
Rabbit Polyclonal Antibody.
Applications: WB: 1:500~1:1000 IHC: 1:50~1:100.
Reactivity: Human.
Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human Caspase 9.
Purification: Immunogen affinity purified.
Reconstitution: 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form of Antibody: Lyophilized.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
Other Caspase 9 Antibodies:
Caspase 9 (Cleaved-Asp330) Polyclonal Antibody
Caspase 9 (Ab-125) Polyclonal Antibody
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