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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal Caspase 2 antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Background
Caspase-2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli. Caspase-2 acts both as a positive and negative cell death effector, depending upon cell lineage and stage of development.
PA000232-ANT-409: CASP2 Monoclonal Antibody
Mouse Monoclonal Antibody.
Applications: Caspase-2 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:500.
Reactivity: Human.
Immunogen: Anti-human Caspase-2 mAb, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human Caspase-2 amino acids 32-169 purified from E. coli.
Purification: Caspase-2 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Form of Antibody: 1 ug/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Clone: P1C10AT.
Isotype: Mouse IgG2b.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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