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Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal BD 4 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Defensins are cationic peptides with a large spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The Alpha defensins are differentiated from the Beta-defensins by the pairing of their 3 disulfide bonds. 4 human Beta-defensins have been identified to date; BD-1, BD-2, BD-3 and BD-4. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Beta-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues.
BP000063-CYT-599: Recombinant Human Beta Defensin-4 (BD-4) Protein
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 50 amino acids and having a molecular mass of 6 kDa.
The activity is determined by its ability to chemoattract human monocytes using a concentration range of 0.1-50 ug/ml.
Purity: > 98% by SDS-PAGE and RP-HPLC.
Formulation: Lyophilized with 20 mM sodium Phosphate buffer pH-7.4 and 130 mM NaCl.
Reconstitution: It is recommended to reconstitute the lyophilized Beta Defensin-4 in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other BD-4 Proteins:
Recombinant Human BD-4 Protein
Recombinant Rat BD-4 Protein
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