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Conditions of optimal BD 4 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
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Introduction
Defensins are cationic peptides with a large spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The Alpha defensins are differentiated from the Beta-defensins by the pairing of their 3 disulfide bonds. 4 human Beta-defensins have been identified to date; BD-1, BD-2, BD-3 and BD-4. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Beta-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues.
BP000063-CYT-066: Recombinant Rat Beta Defensin-4 (BD-4) Protein
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 41 amino acids and having a molecular mass of 4.4 kDa.
The BD-4 is purified by proprietary chromatographic techniques.
The specific activity is measured by its antimicrobial activity against E. coli. The ED50 for this effect is typically 5-50 ug/ml.
Purity: > 97% by SDS-PAGE and RP-HPLC.
Formulation: BD-4 protein was lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Reconstitution: It is recommended to reconstitute the lyophilized BD-4 in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other BD-4 Proteins:
Recombinant Human BD-4 Protein
Recombinant Human BD-4 Protein
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