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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal B-Cell Activating Factor Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
BAFF binds to tnfrsf13b/taci and tnfrsf17/bcma. Tnfsf13/april binds to the same 2 receptors, together, they form a 2 ligands -2 receptors pathway involved in the stimulation of b- and t-cell function and the regulation of humoral immunity. A third b-cell specific baff-receptor (baffr/br3) promotes the survival of mature b-cells and the b-cell response.
B Lymphocyte Stimulator functions as a potent B-cell growth factor in costimulation assays.
Administration of BAFF Human recombinant to mice disrupts splenic B-cell and T-cell zones and results in elevated levels of serum immunoglobulin.
BP000059-CYT-307: Recombinant Human B-cell Activating Factor (BAFF) Protein
Source: E. Coli-derived.
A single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17007 Dalton. The BAFF is purified by proprietary chromatographic techniques.
The Human BAFF activity is determined by a mouse splenocyte survival assay. The ED50 for this effect is 0.5-2.0 ug/ml.
Purity: > 95% by RP-HPLC and SDS-PAGE.
Formulation: Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.0.
Reconstitution: It is recommended to reconstitute the lyophilized BAFF in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
BP000059-CYT-429: Recombinant Human B-cell Activating Factor Receptor
Source: E.Coli-derived.
Determined by its ability to block BAFF induced mouse splenocyte survival. The expected ED50 for this effect is 1000-5000 ug/ml corresponding to a Specific Activity of 200-1000 IU/mg in the presence of 1.0 ug/ml of human soluble BAFF.
Purity > 95%, by RP-HPLC and SDS-PAGE.
Formulation: Lyophilized from a 0.2 um filtered concentrated (1.0 ug/ml) solution in 20 mM PB, pH 8.0, 500 mM NaCl.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
BAFF Antibodies:
BAFF Polyclonal Antibody
BAFF Monoclonal Antibody
BAFF ELISA Kits:
Mouse BAFF ELISA Kit
Human BAFF ELISA Kit
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