My Cart [ 0 ]
Home > Antibodies > A-Z Primary Antibodies > B220 Antibody

B220 Antibody

LCA, PTPRC, LY5, B220, CD45R, T200, GP180, PROTEIN-TYROSINE PHOSPHATASE, RECEPTOR-TYPE C

Catalog No. Product Name Size List Price (US$) Quantity
PA005285-ANT-139 B220 (B cell specific isoform of CD45) Monoclonal Antibody 1 mg 290.00
PA005285-ANT-139 B220 (B cell specific isoform of CD45) Monoclonal Antibody Request
PA005285-ANT-139 B220 (B cell specific isoform of CD45) Monoclonal Antibody 500 ug 160.00
Description

Introduction
B220 (CD45R) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T-and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. B220 (CD45R) is required for t-cell activation through the antigen receptor. The first ptpase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.

PA005285-ANT-139: B220 (B cell specific isoform of CD45) Monoclonal Antibody

Rat Monoclonal Antibody.
Reactivity: Mouse.
Immunogen: Purified mouse LN B cells.
Purification: Ion exchange column.
Form of Antibody: 1ug/ml in PBS (after reconstitution).
Clone: mB220.
Isotype: Rat IgM.

Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.

Related Links

See our Privacy Policy