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Home > Antibodies > Anti-Mouse Antibodies (In Vivo) > Anti-Mouse IFN gamma Monoclonal Antibodies

Anti-Mouse IFN gamma Monoclonal Antibodies

Interferon-gamma, Immune interferon, Type II interferon, T cell interferon, Macrophage-activating factor (MAF), IFN-g, IFN-gamma

Catalog No. Product Name Size List Price (US$) Quantity
PA007546.r1 In Vivo Grade Recombinant Anti-mouse IFN gamma Monoclonal Antibody (Clone: R4-6A2), Rat IgG1 Kappa 1 mg 150.00
PA007546.r1 In Vivo Grade Recombinant Anti-mouse IFN gamma Monoclonal Antibody (Clone: R4-6A2), Rat IgG1 Kappa 5 mg 350.00
PA007546.r1 In Vivo Grade Recombinant Anti-mouse IFN gamma Monoclonal Antibody (Clone: R4-6A2), Rat IgG1 Kappa 25 mg 900.00
Description

PA007546.r1: In Vivo Grade Recombinant Anti-mouse IFN gamma Monoclonal Antibody (Clone: R4-6A2), Rat IgG1 Kappa

Recombinant Rat IgG1 Monoclonal Antibody.
Clone: R4-6A2.
Isotype: Rat IgG1 kappa.
Source: The anti-mouse IFN-γ monoclonal antibody (clone: R4-6A2) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant rat monoclonal antibody (clone: R4-6A2) specifically binds to mouse IFN-γ.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse IFN-γ protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.

Shipping: The in vivo grade recombinant anti-mouse IFN-γ monoclonal antibody of clone R4-6A2 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

References of Anti-mouse IFN gamma Monoclonal Antibody

Choi, I. K., et al. PLoS One. 2013 Jul 3;8(7):e67512. PMID: 23844018
The levels of IL-12, IL-23, interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) were elevated in RdB/IL23/p35-treated tumors. ...Moreover, the proportion of regulatory T cells was markedly decreased in mice treated with RdB/IL23/p35. ...Importantly, therapeutic mechanism of antitumor immunity mediated by RdB/IL23/p35 is associated with the generation and recruitment of IFN-gamma- and TNF-alpha-co-producing T cells in tumor microenvironment.
(Tags: anti-mouse IFN gamma R4-6A2 mAb in cancer research; anti-mouse IFN gamma R4-6A2 antibody in mouse tumor model)
Wu, H. Y., et al. PLoS One. 2011 Aug 23;6(8):e23618. PMID: 21886804
Upon T-cell receptor (TCR) mediated activation, Tr1 cells produce high levels of IL-10 and transforming growth factor-beta (TGF-beta), low levels of interferon-gamma (IFN-gamma) and almost no IL-2 or IL-4. ...Upon activation with anti-CD3 in vitro, FACS sorted CD4+CD25-GFP(IL-10)+ T cells secreted IL-10 and IFN-gamma. ...Concomitant with the deficient generation of LAP+ Tr1 cells, we found that CD4+ T cells from IL-27R-/-/lpr mice given nasal anti-CD3 produced significantly higher amounts of IFN-gamma and IL-12 upon in vitro stimulation with anti-CD3.
(Tags: anti-mouse IFN gamma R4-6A2 antibody of low endotoxin; anti-mouse IFN gamma antibody R4-6A2)
For more technical references or data sheets regarding the Anti-mouse IFN gamma Monoclonal Antibody formats, please contact our scientific support team at message@sydlabs.com.
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