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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Recombinant rat IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant Rat IgG1 Monoclonal Antibody.
Clone: R4-6A2.
Isotype: Rat IgG1 kappa.
Source: The anti-mouse IFN-γ monoclonal antibody (clone: R4-6A2) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant rat monoclonal antibody (clone: R4-6A2) specifically binds to mouse IFN-γ.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse IFN-γ protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The in vivo grade recombinant anti-mouse IFN-γ monoclonal antibody of clone R4-6A2 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
Oncolytic adenovirus expressing IL-23 and p35 elicits IFN-?- and TNF-?-co-producing T cell-mediated antitumor immunity.
Choi, I. K., et al. PLoS One. 2013 Jul 3;8(7):e67512. doi: 10.1371/journal.pone.0067512. PMID: 23844018
The levels of IL-12, IL-23, interferon-? (IFN-?), and tumor necrosis factor-? (TNF-?) were elevated in RdB/IL23/p35-treated tumors. ...Moreover, the proportion of regulatory T cells was markedly decreased in mice treated with RdB/IL23/p35. ...Importantly, therapeutic mechanism of antitumor immunity mediated by RdB/IL23/p35 is associated with the generation and recruitment of IFN-?- and TNF-?-co-producing T cells in tumor microenvironment. ...IL-12 stimulates interferon-? (IFN-?) and tumor necrosis factor-?TNF-?production by natural killer (NK) cells and T cells, eliciting promoted the T helper 1 (Th1) immune response. ...In addition,IL-23 has been shown to have significant antitumor effects in various establishment models of cancer, making it an important candidate for cancer immunogene therapy.
Tags: anti-mouse IFN gamma R4-6A2 mAb in cancer research; anti-mouse IFN gamma R4-6A2 antibody in mouse tumor model
In vivo induction of Tr1 cells via mucosal dendritic cells and AHR signaling.
Wu, H. Y., et al. PLoS One. 2011 Aug 23;6(8):e23618. doi: 10.1371/journal.pone.0023618. PMID: 21886804
Upon T-cell receptor (TCR) mediated activation, Tr1 cells produce high levels of IL-10 and transforming growth factor-beta (TGF-?), low levels of interferon-gamma (IFN-?) and almost no IL-2 or IL-4. ...Upon activation with anti-CD3 in vitro, FACS sorted CD4+CD25-GFP(IL-10)+ T cells secreted IL-10 and IFN-?. ...This cytokine pattern is consistent with a Tr1 cell phenotype,and was not seen when CD4+CD25-GFP(IL-10)- naive T cells or CD4+CD25+GFP(IL-10)- T cells were sorted from anti-CD3 treated mice and activated in vitro ...We found that freshly isolated CD4+CD25-GFP(IL-10)+ Tr1 cells induced by treatment with nasal anti-CD3 consistently expressed high levels of il10 and also some ifng, however foxp3 expression was undetectable. ...Concomitant with the deficient generation of LAP+ Tr1 cells, we found that CD4+ T cells from IL-27R?/?/lpr mice given nasal anti-CD3 produced significantly higher amounts of IFN-? and IL-12 upon in vitro stimulation with anti-CD3.
Tags: anti-mouse IFN gamma R4-6A2 antibody of low endotoxin; anti-mouse IFN gamma antibody R4-6A2
For more references about Anti-mouse IFN gamma Monoclonal Antibody please contact our scientific support team with message@sydlabs.com.
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