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Home > Antibodies > Anti-Mouse Antibodies (In Vivo) > Anti-Mouse TGF-beta Monoclonal Antibodies

Anti-Mouse TGF-beta Monoclonal Antibodies

Transforming Growth Factor-Beta, TGFB, TGF-beta2, TGFB1

Catalog No. Product Name Size List Price (US$) Quantity
PA007512.m1 In Vivo Grade Recombinant Anti-mouse/human/rat/monkey/hamster/canine/bovine TGF-beta Monoclonal Antibody (Clone: 1D11.16.8), Mouse IgG1 Kappa 1 mg 150.00
PA007512.m1 In Vivo Grade Recombinant Anti-mouse/human/rat/monkey/hamster/canine/bovine TGF-beta Monoclonal Antibody (Clone: 1D11.16.8), Mouse IgG1 Kappa 5 mg 350.00
PA007512.m1 In Vivo Grade Recombinant Anti-mouse/human/rat/monkey/hamster/canine/bovine TGF-beta Monoclonal Antibody (Clone: 1D11.16.8), Mouse IgG1 Kappa 25 mg 900.00
Description

PA007512.m1: In Vivo Grade Recombinant Anti-mouse/human/rat/monkey/hamster/canine/bovine TGF-β Monoclonal Antibody (Clone: 1D11.16.8), Mouse IgG1 Kappa

The in vivo grade recombinant anti-mouse/human/rat/monkey/hamster/canine/bovine TGF-β mouse IgG1 kappa monoclonal antibody was produced in mammalian cells. 
Clone: 1D11.16.8.
Isotype: Mouse IgG1 Kappa.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: 1D11.16.8) specifically binds to mouse/human/rat/monkey/hamster/canine/bovine TGF-β.
Applications: ELISA, flow cytometry, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the TGF-β protein. 
Formulation: 0.2 μM filtered solution of 1x PBS.
Purity: >95% by SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU/mg of protein as determined by LAL method.

Shipping: The in vivo grade recombinant anti-mouse/human/rat/monkey/hamster/canine/bovine TGF-β antibodies (clone of 1D11.16.8) are shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

Related Recombinant IgG Reference Antibodies:
In vivo grade recombinant mouse IgG1 isotype control antibody

References of Anti-mouse/human/rat/monkey/hamster/canine/bovine TGF-beta Monoclonal Antibody (Clone: 1D11.16.8)

Transforming Growth Factor-? and Interleukin-10 Synergistically Regulate Humoral Immunity via Modulating Metabolic Signals.
Komai, T., et al. Front Immunol. 2018 Jun 14;9:1364. PMID: 29963056
Inhibitory cytokines like transforming growth factor-? (TGF-?) and interleukin-10 (IL-10) are key regulators of immune homeostasis, as mice deficient for either of these regulatory cytokines develop severe inflammatory diseases. Blockade of pro-inflammatory cytokines offers effective treatment of inflammatory autoimmune diseases such as rheumatoid arthritis. ...The effects of representative inhibitory cytokines, TGF-?, and IL-10, on B cells have been examined. ...Anti-IL-10 mAb (300 ?g) (JES5-2A5, Bio X Cell, West Lebanon, NH, USA) and 300 ?g anti-TGF-? antibody (1D11.16.8, Bio X Cell) were administered i.p. at day -1, 2, and 5.
(Tags: anti-mouse TGF beta; anti-mouse TGF beta 1D11.16.8 mAb)
TGF-? Blockade Reduces Mortality and Metabolic Changes in a Validated Murine Model of Pancreatic Cancer Cachexia.
Greco, S. H., et al. PLoS One. 2015 Jul 14;10(7):e0132786. PMID: 26172047
Potential immunologic targets for cachexia treatment in PDA, include Toll-like receptors (TLRs) and transforming growth factor beta (TGF-?). ...The transforming growth factor beta (TGF-?) pathway plays an important role in cell differentiation and inflammation. ...However, at the same time TGF-? blockade may reduce the invasiveness of PDA. ...For immunohistochemical analysis, paraffin-embedded tissue sections were stained using polyclonal anti-TGF-? (1:100; Abcam, Cambridge, MA), anti-p21 (1:100, Santa Cruz), or anti p-Smad 2/3 (1:50, Santa Cruz) and the corresponding isotype controls. ...Collectively, these data suggest that targeting TGF-? is an attractive strategy for targeting pancreatic cancer cachexia.
(Tags: anti-mouse TGF beta 1D11.16.8 antibody of low endotoxin)
Loss of the TGF-?-activating integrin ?v?8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity.
Worthington, J. J., et al. PLoS Pathog. 2013;9(10):e1003675. PMID: 24098124
Using a model parasite which infects mice, we find that a protein called transforming growth factor beta (TGF-?) signals to T-cells early during the development of chronic infection and that blocking this signal protects mice from infection. ...We have also uncovered a key pathway and cell type that controls TGF-? function during development of chronic infection. ...A key cytokine that plays a multi-functional role in controlling immune responses is transforming growth factor beta (TGF-?). ...Given its importance in regulating diverse T-cell responses, it is not surprising that TGF-? plays a crucial role in the maintenance of immune homeostasis and prevention of autoimmunity. ...However, the function of TGF-? during helminth infection and how it is regulated to control immune responses to intestinal parasites is poorly understood.
(Tags: anti-mouse TGF beta (1D11.16.8) in vivo antibody; anti-mouse TGF beta antibody 1D11.16.8)
For more technical references or data sheets regarding the Anti-mouse/human/rat/monkey/hamster/canine/bovine TGF-beta Monoclonal Antibody (Clone: 1D11.16.8) formats, please contact our scientific support team at message@sydlabs.com.
Related Links
Anti-mouse/human/rat/monkey/hamster/canine/bovine TGF-beta 1D11.16.8 Monoclonal Antibody, Mouse IgG1 Kappa
Anti-Mouse TGF-beta Monoclonal Antibodies for Flow Cytometry(Clone: 1D11.16.8)
Anti-mouse/human/rat/monkey/hamster/canine/bovine TGF-beta 1D11.16.8 Antibody for Flow Cytometry, Mouse IgG1 Kappa
Biotinylated Cynomolgus GARP&Latent TGF beta 1 Complex Protein
Biotinylated Human Latent TGF beta 1 Protein
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