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Recombinant rat IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant Rat IgG2a Monoclonal Antibody.
Clone: 1G10.
Isotype: Rat IgG2a Kappa.
Source: The anti-mouse CD80 (B7-1) monoclonal antibody (clone: 1G10) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant rat monoclonal antibody (clone: 1G10) specifically binds to mouse CD80 (B7-1).
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CD80 (B7-1) protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The in vivo grade recombinant anti-mouse CD80 (B7-1) monoclonal antibody of clone 1G10 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
Plasma membrane vesicles decorated with glycolipid-anchored antigens and adjuvants via protein transfer as an antigen delivery platform for inhibition of tumor growth.
Patel, J. M., et al. Biomaterials. 2016 Jan;74:231-244. doi: 10.1016/j.biomaterials.2015.09.031. PMID: 26461116
Purified anti-mIL-12 p40 mAb (C17.8) and anti-mB7-1 mAb (1G10) were obtained from Bio X Cell. ...Tricistronic viral vectors co-expressing interleukin-12 (1L-12) and CD80 (B7-1) for the immunotherapy of cancer: preclinical studies in myeloma. ...Construction, purification, and functional incorporation on tumor cells of glycolipid-anchored human B7-1 (CD80). ...PMVs are derived from cellular membranes and thus contain a lipid bilayer making them amenable to protein transfer. ...The extracellular domain (ECD) of HER-2 is attached to the GPI-anchor signal sequence from CD59 and cloned into a pUB6 vector (B) PI-PLC treatment of CHO-K1 cells transfected with HER-2.
Tags: anti-mouse CD80 (B7-1) 1G10 in cancer research; anti-mouse CD80 (B7-1) 1G10 in mouse tumor model
PD-L1 limits the mucosal CD8+ T cell response to Chlamydia trachomatis.
Fankhauser, S. C., et al. J Immunol. 2014 Feb 1;192(3):1079-1090. doi: 10.4049/jimmunol.1301657. PMID: 24353266
Chlamydia trachomatis infection is the most common bacterial sexually transmitted disease in the United States. ...Repeated infections with C. trachomatis lead to serious sequelae, such as infertility. ...It is unclear why the adaptive immune system, specifically the CD8+ T cell response, is unable to protect against subsequent C. trachomatis infections. ...In this article, we characterize the mucosal CD8+ T cell response to C. trachomatis in the murine genital tract. ...We demonstrate that the immunoinhibitory ligand, PD-L1, contributes to the defective CD8+ T cell response.
Tags: anti-mouse CD80 (B7-1) antibody (1G10); anti-CD80 (B7-1) clone 1G10
B7-1 and B7-2 co-stimulatory molecules are required for mercury-induced autoimmunity.
Bagenstose, L. M., et al. Clin Exp Immunol. 2002 Jan;127(1):12-19. doi: 10.1046/j.1365-2249.2002.01700.x. PMID: 11882027
B7-1 (CD80) and B7-2 (CD86) molecules on antigen presenting cells play important roles in providing co-stimulatory signals required for activation and expansion of autoreactive T cells. ...The mechanisms responsible for the various manifestations of this syndrome have yet to be elucidated. ...Additionally, single anti-B7-1 antibody treatment was sufficient to prevent Hg-induced ANoA production, but not IgG1 and IgE hypergammaglobulinaemia. ...Further, single anti-B7-2 antibody treatment resulted in a partial reduction of ANoA titres but had no significant effect on total serum IgG1 and IgE levels. ...Taken together, these results indicate that B7-1 and B7-2 molecules are critical for the development of Hg-induced autoimmunity and suggest that the different manifestations of the syndrome are regulated by independent mechanisms.
Tags: function of anti-mouse CD80 (B7-1) 1G10 antibody; bioactivity of anti-mouse CD80 (B7-1) 1G10
For more references about Anti-mouse CD80 (B7-1) Monoclonal Antibody please contact our scientific support team with message@sydlabs.com.
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