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Recombinant mouse IgG2a Monoclonal Antibody.
Clone: 5c8.
Isotype: Mouse IgG2a kappa.
Source: The anti-human/monkey CD40L (CD154) monoclonal antibody (clone: 5c8) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: 5c8) specifically binds to human/monkey CD40L (CD154).
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human/monkey CD40L (CD154) protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The in vivo grade recombinant anti-human/monkey CD40L (CD154) monoclonal antibody of clone 5c8 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
Contributions of direct and indirect alloresponses to chronic rejection of kidney allografts in nonhuman primates.
Nadazdin O, et al. J Immunol. 2011 Nov 1;187(9):4589-97. doi: 10.4049/jimmunol.1003253. PMID: 21957140
The relative contribution of direct and indirect allorecognition pathways to chronic rejection of allogeneic organ transplants in primates remains unclear. ...In this study, we evaluated T and B cell alloresponses in cynomolgus monkeys that had received combined kidney/bone marrow allografts and myeloablative immunosuppressive treatments. ...We measured donor-specific direct and indirect T cell responses and alloantibody production in monkeys (n = 5) that did not reject their transplant acutely but developed chronic humoral rejection (CHR) and in tolerant recipients (n = 4) that never displayed signs of CHR. All CHR recipients exhibited high levels of anti-donor Abs and mounted potent direct T cell alloresponses in vitro. ...Such direct alloreactivity could be detected for more than 1 y after transplantation. ...No indirect alloresponse by T cells and no alloantibody responses were found in any of the tolerant monkeys.
Tags: anti-human CD40L (CD154) 5c8 of low endotoxin; anti-human CD40L (CD154) 5c8 antibody of low endotoxin
For more references about Anti-human/monkey CD40L (CD154) Monoclonal Antibody please contact our scientific support team with message@sydlabs.com.
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