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Background Information:
A potent and selective ATP-competitive inhibitor of Aurora B kinase with an in vitro IC50 values of 50, 250 and 1000 nM for Aurora B, C and A kinases, respectively. Selective over a range of other kinases including cdk1 and PLK1 (IC50 > 10 μM). Inhibits cell division and displays selective toxicity towards proliferating tumor cells versus non-dividing cells.
Reference:
1. C. Ditchfield et al., J. Cell Biol., 2003, 161, 267; 2. Z. J. Long et al., J. Cell Cycle, 2008, 7, 1473; 3. E. Walsby et al,. Haematologica, 2008, 93, 662.
APIM050266: ZM447439
CAS No.: 331771-20-1.
Molecular Formula: C29H31N5O4 ? 3H2O.
Molecular Weight: 567.71.
Purity: >99% (HPLC).
QC: 1HNMR, HPLC.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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