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Conditions of optimal Vimentin antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Vimentin expression in human malignant glioma cells depends on cellular density, algorithms of drug delivery and chemo/radio treatment. Vimentin and detyrosinated microtubules provide structural support for the extensive microtentacles observed in detached tumor cells and a mechanism to promote successful metastatic spread. Primary colorectal carcinomas display aberrant expression of vimentin, and have activated Notch and TGFbeta signaling pathways. Vimentin is a strong arterial substrate for transglutaminases. Transglutaminase-mediated vimentin dimerization results in a novel unifying pathway by which vasodilatory and remodeling responses may be regulated. Ablation of vimentin expression inhibits migration and invasion of colon and breast cancer cell lines.
PA000101-ANT-245: Vimentin Monoclonal Antibody
Mouse Monoclonal Antibody.
Applications: Direct ELISA, Western Blot, Immuneprecipitation, immunohistochemistry. For intra-cellular staining, use 5-10 ul/106 cells. Wash twice with PBS/Azide before adding the appropriate amount of secondary fluorescent reagent.
Reactivity: Human.
Immunogen: Purified Human Vimentin.
Purification: Ion exchange column.
Form of Antibody: 1ug/ml in PBS (after reconstitution).
Clone: hVimentin.
Isotype: mouse IgG1.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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